The leg press machine is a great way to work multiple leg muscles. The quads, hamstrings, glutes, and calves are all worked hard during this exercise. There are different kinds of leg press machines, but the basis is the same: You draw the knees in and then extend the legs with as much weight as you can.
Here is a great video to show you how to do this exercise. Make sure you do not lock your knees as you extend your legs because this could cause injury. And of course while you should not be a pansy with the weight, do not go overboard as well. Learn to know your limits.
Cheers Eights & Weights!